Pathology
Pathology

The Department of Pathology was established in 2005. The Department strives to provide excellence in teaching, diagnostic services and research and is well recognized for its dedicated and innovative approach towards providing accurate and timely diagnostic services in all facets of surgical & anatomic pathology, haematology, coagulation,clinical pathology and cytology to patients from Chengalpattu district, Chennai and other cities of Tamil Nadu& neighboring states.

Department of Pathology is presently headed by Prof. Dr. R. Vijayashree,who has an experience of 20 years in both diagnostic and teaching services and about 30 publications to her credit. The young vibrant team of pathology consists of well qualified.(MD/DNB) and trained faculty (professors, associate professor & assistant professor & tutors) and has established its mark in all three aspects of Heath care, Patient Care, Teaching & Research.

The hematology, clinical pathology, cytology & histopathology basic services are available round the clockand are complemented by specialized Rapid Diagnostic Frozen section, Immunohistochemistry & Immunofluorescence services in both adult & Paediatric pathology,all under one roof which is NABL accredited laboratory since 2009.

The laboratory is well equipped with state of art equipment including Fully Automated Haematology Analyzers, Automated Coagulation Analyzers, Automated ESR Analyzer, Automated Urine analyzer, and QBC for MP/MF. Apart from these, Rapid Tissue Processors, Automated Paraffin Embedding Stations, Automated Microtomes for tissue sectioning, Cryostats (Rapid Tissue sections) and Multi-headed (Decahead) microscopes. All laboratory test results are available through the hospital intranet, as part of the Laboratory Information System (LIS).We are committed to a rapid turn-around-time while providing the highest quality patient care.

3.1. Blood Bank (Diagnostic & Therapeutic services)

  • The Blood Bank works 24 x7 to cater to the blood component requirements of the hospital. We have an active component preparation section. Currently we are preparing components in more than 98% of collections.
  • The Serology section has an Automated System (Gel Technology) for reporting of blood groups and other immunohaematological tests. The Blood bank has facilities to investigate for a limited red cell antibody screening and identification.
  • The blood bank also has facilities for Plasma & single donor Platelet pheresis to cater to patients with GBS, Dengue fever, Thrombocytopenia. The blood bank provides exchange transfusion therapy for patients with Rat Killer poisoning. Blood Bank provides support to patients with Hemophilia and related Bleeding disorders and Thalassemia

The Department of Pathology deals with teaching responsibilities as well. Department is involved in teaching Undergraduate (MBBS) and Postgraduate (MD Pathology) Medical students, Undergraduate and Postgraduate Allied Health Sciences Students, Undergraduate & postgraduate Physiotherapy, Pharmacy, Nursing and Dental Students.We have a large museum with a display of around 350 mounted specimens in all systems and 600 wet specimens for postgraduate learning.

Undergraduate training & learning is accomplished by means of Interactive lectures and small group discussions, Assignments, Seminar presentation, Case resolutions.Innovative Teaching Learning and Evaluation Methods for Undergraduates include the introduction of integrated OSPE stations for urine analysis & blood grouping, Project Exhibitions, Quiz/Debate, Problem Based Learning and Online Image Quiz

Training Programsfor Postgraduatesincludesslidediscussions, discussions on morbid anatomy,short topics, techniques, Journal club, student seminars, Autopsy Discussions, Periodical thesis reviews. Scheduled rotational postings in subspecialty departments are also organized. Interdepartmental meets conducted once in a month with the clinical departments. Faculty also participate and present cases in Clinicopathological meets. Innovative Teaching Learning Methods for Postgraduates include the introduction of integrated OSPE stations for histopathology techniques, E based learning of gross & histopathology case discussions, Skill Lab, Gross Photography and Mounting Specimens

Knowledge is imparted to the Allied Health Science students thorough theory classes, clinical case discussion, hands on training and they also have to submit a research project.

Faculty regularly update their knowledge by attending workshops and conferences and faculty development programs to hone their teaching skills.

All faculty actively participate in research with many completed projects, ongoing projects and publications individually. Also, department is involved in many collaborative research projects from College of Allied Health Sciences including Molecular/Genomic/Nanotechnology areas.

Major thrust area for research include Molecular Biomarkers Study in Breast Cancer, Chronic diseases like Psoriasis, H.pylori induced Gastritis and Adenocarcinoma, Ovarian Malignancies, Cervical Neoplasia and Colorectal Carcinomas.

The Department actively organizes conferences and CMEs on updates in pathology inviting eminent pathologists and scientists for guest lectures. Faculty and PG/UG students’ active participation in Local, Regional, National & International conferences including giving Guest Lectures, Chairing scientific sessions and Oral paper/Poster presentations.

Completed & Ongoing Projects – 50 completed projects in last 10 years and 10 ongoing projects in the current year. Publications – 85 publications in last 10 years in Local, State, National & International level Journals with 50% in Scopus& WoS.

25 ICMR STS projects have been awarded in Pathology from 2008 till date, in addition to 25 CARE funded projects & 2 Care Seed projects

  • Hematology & Immunohematology
    Complete Haemogram, QBC, Osmotic Fragility tests, HPLC in conjunction with Biochemistry, clinical workups for hemolytic & Nutritional Anemias, DCT & ICT
  • Coagulation profile studies including routine PT/APTT, mixing studies, Fibrinogen, D-Dimer and selective Factor assay, Work up of Bleeding and thrombotic disorders.

Clinical Pathology services include Automated Urinanalysis, all Body fluid tests & Semen analysis.Clinical Pathologists perform quality assurance and supervision, provide interpretations of more complex results, and serve as consultants to clinicians to determine the appropriate testing for the diagnosis or the assessment of an individual patient’s condition.

  • Histopathology section including Synaptic Reporting of Breast, Colon, Stomach, Ovarian& Uterine Carcinomas–we as anatomic pathologists have been moving more and more toward the molecular level to gain additional clinical information on individual specimens. Surgical pathology is a large area of practice for anatomic pathologists, involving examination of surgical specimens and biopsies from patients.
  • Frozen Sections for rapid diagnosis including intra-operative consultations by the department of pathology
  • Transplant biopsies (Renal, &Liver) are reported periodically.
  • Autopsy pathology accounts for less than ten percent of the work of pathologists, it is the most commonly understood function of the pathologist. Clinical Fetal Autopsy services- Autopsies remain an important area of the modern practice of pathology and they are often equated in the popular imagination with it.

Cytopathology service provides a full range of cytology services, including exfoliative cytology and the performance of fine needle aspiration under guidance or freehand.

  • Immunofluorescence on renal and skin biopsies
  • Immunohistochemistry with a panel of about 40 antibodies in all Breast cancers, GIT cancers, Small blue round cell tumours, Soft tissue sarcomas, Lymphoproliferative disorders & Undifferentiated malignancies
  • Department of Pathology focuses on an integrative approach to the field, in which scientists and physicians strive to work in conjunction with each other to integrate the knowledge gained in research with the needs for patient care.
  • Apart from academic excellence, the Department aims to strengthen molecular pathology with our College of Allied Health Sciences Molecular Department to enhance the efficiency of subspecialty branches under Pathology and also strives towards becoming a collaborative high impact research facility.
S.No Name of the Investigators Title Funding Agency(if any) Commenced on Fund allotted
1 Dr. Deepak Dubey,

Prof. Vijayashree. R

Correlation between geriatric anemia and selective inflammatory biomarkers – A case control study. Nil 2019 Self
2 Dr. C. Divya Priya Expression of CD4 & CD8 biomarkers on intraductal breast carcinoma Nil 2019 Self
3 Dr. Pooja E. Moorthy,

Prof. Rajesh Kanna

A study method on demonstration of CAG-A, a mRNA-based biomarker from H.pylori infected patients stool samples. Nil 2019 Self
4 Dr. Femela,

Ms. Pavithra Lakshmi

Study to evaluate the effect of edentulism on nutritional status, RBC parameters & erythrocyte sedimentation rate CARE 2019 Self
5 Dr. M. Femela,

Prof. R. Vijayashree

Serial estimation of levels of coagulation factors in different plasma preparations CARE SEED 2019 CARE
6 Dr. Aarthi.K,

Prof. R Vijayashree

Expression of Anti – apoptotic markers in different molecular subtypes of invasive ductal carcinoma( no special type ) with clinicopathological correlation CARE SEED 2019 CARE
7 Dr. M. Femela Evaluation of the blood parameters for their role in assessing the severity of the coronary artery disease CARE 2020
8 Prof. R. Vijayashree Relationship between Waist circumference &haematological parameters with pulmonary function tests in overweight & obese individuals. ICMR 2020
9 Dr. M. Femela,

Ms. Lithiyashree

Study of the effect of storage on RBC indices and RDW CARE 2020
10 Dr Devi.S

Aditi M Jain

Agar cell suspension for processing fluid specimens – A cost and resource effective cell enrichment cytology technique Submitted for IHEC approval 2020
11 Dr. D.RajeswariThivya KarunyaVarshini. B A study of role of mean platelet volume and platelet distribution width in chronic obstructive pulmonary disease ICMR
Submitted for IHEC approval
2020
12 Dr. D.RajeswariThivya
Meghanath. K
A retrospective study of blood donor deferral pattern in a tertiary care carecentre – A 3 year study CARE 2019
13 Dr.T.AyeeshaSithika
JaganathanPalanivel
Study of frequency of morphological markers of chromosomal instability in cervical smears of normal, inflammatory and intraepithelial neoplasm. ICMR
Submitted for IHEC approval
2020
14 Dr. Jane Betsy Isaac,

Prof Vijayashree R

A cross sectional study to evaluate serum vitamin B12, homocytsteine and hematological parameters in ischemic stroke patients at a tertiary care centre Nil 2019 Self
15 Dr Gayathri Devi S

Dr S Devi

Expression ID4 protein and its correlation with angiogenesis in breast cancer Nil 2019 Self
16 Dr. Priyadharshini.K

Dr N R Rajesh Kanna

Role of glial mesenchymal transition in the pathogenesis of high grade glioma Nil 2019 Self
17 Dr. Aarthi K,

Raghav R

Estimation of reference ranges complete blood count (CBC) of healthy antenatal indian women Nil 2020
18 Dr.Aarthi K,

Divya

Comparison of routine urinalysis and enhanced urinalysis with pyuria in children Nil 2020 Self
19 r Aarthi K,

Abirami

Study of platelet histograms in pseudothrombocytopenia Nil 2020 self
20 Dr. Vijayashree,

Dr. Rajesh,

Dr. Devi,

Dr. Priyadarshini,

Dr. Mohan,

Dr. Prabhu

The role of hematological, coagulation, biochemical parameters and urinalysis in assessing the severity of COVID-19 CARE 2020
S.No Name of the Investigators Title Funding Agency(if any) Period
1 Dr. C. Chidambharam, Assistant Professor,

Mr. Anish Sunder Narayanan

Effect of adjusted and non-adjusted citrate concentrations on coagulation test results in patients with high haematocrit values – Breaking the unproven leap of faith ICMR STS 2011
2 Ms. S. Valli (MBBS student),

Dr. Rajesh Kanna, Assistant Professor

Relation between Diabetes mellitus type 2 and cognitive impairment, a predictor of Alzheimer’s disease ICMR STS 2011
3 Mr Treshul Kumar (MBBS student),

Prof Dr S Balamurugan

Automated Measurement of Immature Granulocytes : Performance Characteristics and Utility in Routine Clinical Practice ICMR STS 2011-12
4 Prof S. Balamurugan Reagent Strip Testing for Asymptomatic Bacteriuria in Pregnant Women : A Cost Effective Screening Tool in Under-sourced Settings CARE 2011-12
5 Dr R Vijayashree (Associate Professor)

MsTejasvee (MBBS student),

Relation between Lung function and RBC distribution width in a population based study ICMR STS 2012
6 Dr. Aruthra (MD student, Pathology) Molecular subtyping of Breast Carcinoma Using IHC and Clinico-pathological Correlation CARE 2012-14
7 Dr. M. Femela, Assistant Professor Evaluation of auto analyzer generated pseudobasophilia. CARE 2012-14
8 Ms. Bageerathi (MBBS student),

Dr. Sushma Nayar, Associate Prof

Risk Factors For Coronary Artery Disease in a Semi-urban Area of Tamil Nadu, Especially Pertaining to Tobacco Use ICMR STS 2013
9 Ms.Swathika(MBBS student),

Dr. Aarthi Kannan, Assistant Prof

Effects of Thyroid Dysfunction on Prothrombin Time and Activated Partial Thromboplastin Time ICMR STS 2013
10 Dr.R.Vijayashree, Associate Professor

V. R. Abhirami (MBBS student),

RDW as a Prognostic Marker in Patients with Stroke ICMR STS 2014
11 Ms. Preethi Ravi (MBBS student),

Dr. S. Devi

Predictive Value of Platelet Indices in the Spectrum of Ischaemic Heart Disease ICMR STS 2014
12 K. Hemanth Kumar (MBBS student),

Prof. Dr. S. Balamurugan

Self-directed Learning Among UG Medical Students ICMR STS 2014
13 Mr. Diwaker (BDS student)

Associate Prof Dr. N. R. Rajesh Kanna

MPV in Type II Diabetes Mellitus ICMR STS 2014
14 Dr P Aruthra (MD student, Pathology),

Dr R Vijayashree,

Dr Ramesh Rao

Automated Quantitation of Receptor status of breast carcinoma with Immunohistochemical reclassification CARE 2014-15
15 Dr R Vijayashree,

Dr K Ramesh Rao

Morphometric Assessment of Nuclei in Squamous cell carcinoma in comparison with Pseudoepitheliomatous hyperplasia and Verrucous carcinoma – An image J Based semi-Automated study CARE 2014-15
16 Dr R Vijayashree,

Dr K Ramesh Rao

Morphometric Assessment of Nuclei in Pap Smears with Reactive changes, ASCUS, LSIL & HSIL using ImageJ – Semi Automated analysis. CARE 2014-15
17 Dr. Siva Prashanth (MD student, Pathology),

Prof. k. Ramesh Rao

Relationship Between Red Cell Distribution Width And Other Haematological Parameters With HbA1C Values In Diabetic Patients CARE 2014-15
18 Dr K Sivaprashanth (MD student, Pathology),

Prof K Ramesh Rao

Platelet indices and other haematological parameters in Type II DM with complications CARE 2014-15
19 Dr. Teena Eugene (MD student, Pathology),

Prof. R. Vijayashree,

Dr. Rajesh Kanna (Associate Professor)

Rapid Intraoperative Diagnosis of CNS Tumors by Squash Cytology and its Correlation with Histopathology CARE 2014-16
20 Dr R Vijayashree, Professor

Ms Dhamini Gunasekaran (MBBS student)

Relevance of Haematologic Parameters in Obese Women with or without Metabolic Syndrome. ICMR STS 2015
21 Dr Teena Eugene,

Dr R Vijayashree,

Dr Rajesh Kanna

Rapid Intraoperative Diagnosis of CNS Tumors by Squash Cytology and its Correlation with Histopathology CARE 2015
22 Dr R Vijayashree

Ms Abhinaya Kuberan (MBBS student)

MPV and other haematological parameters in psoriatic patients. ICMR STS 2016
23 Dr Rajesh Kanna,

Ms Snigdha (MBBS student)

Estimation of platelets counts and other haematological parameters in pseudothrombocytopenia using alternate anticoagulant Magnesium sulphate ICMR STS 2016
24 Dr Aarthi K, Assistant Professor,

Ms Pavithra Selvam (MBBS student)

The potential of using VCS parameters of neutrophils as an early diagnostic tool in acute bacterial infections. ICMR STS 2016
25 Dr FemelaMuniraj, Associate Professor,

Ms. Saipriya Mohan (MBBS student)

Comparison of the traditional method of counting platelets in peripheral smear with the alternative methods in case of Erythropenia. CARE 2016-17
26 Dr. S. Devi

Ms. Ananthalakshmi (MBBS student)

The effects of sample transport by pneumatic tube system on routine hematology and coagulation systems ICMR STS 2017
27 Dr Rajesh Kanna, Professor,

Ms. AbishkaufJenishBeautlin, AHS student

Correlation between cytology and histopathology of salivary gland lesions CARE 2017
28 Dr. Femela Muniraj, Associate Professor,

Ms. Helen Monisha, AHS student

Comparison of Papanicolaou and Diff-Quik stains in differentiation of round cells in semen. CARE 2017
29 Dr. R Vijayashree, Professor,

Ms. Maivizhi, MBBS student

Mean Platelet Volume and Red cell Distribution width in clinical and subclinical Hypothyroidism CARE 2017
30 Dr. Sushma Nayar,

Ms. SriRanjani, MBBS student

Rebound eosinophilia as a marker of recovery in dengue cases CARE 2017
31 Dr.Chidambharam, Assistant Professor,

Balamurugan, AHS student

Prevalence of pre-analytical errors in haematology laboratory CARE 2017
32 Dr.Aarthi K, Associate Professor,

Yogesh, AHS student

Comparison of rapid and conventional Pap stain in gynaecology and non-gynaceology specimens CARE 2017
33 Dr. Femela Muniraj, Associate Professor,

Ms. T. Radhalakshmi, MBBS student

Evaluation of Leucocyte Esterase Test in analysis of body fluids other than blood & urine using reagent strips CARE 2017-2018
34 Dr R Vijayashree

MsSarmita Pal, II yr MBBS

Effect of GERD on Pulmonary Function Test and hematological parameters Case Control study ICMR STS 2018
35 Dr ChidambharamMs Shruti,

II yr MBBS

Demystifying the mysteries of Megaloblastic Anemia: Volume, Conductance, Scatter of hypersegmented neutrophils and elucidating the pathogenesis of in vitro hemolysis in megaloblastic anemia ICMR STS 2018
36 Dr T Bhuvaneeswari

Ms. Malini II yr MBBS

The usefulness of cell population data of leucocytes in accurately predicting the etiology of acute febrile illness. ICMR STS 2018
37 Dr. BhuvaneeswariThiyagarajan,

M.kavitha, AHS student

A comparative study on the usefulness of unstained and stained peripheral blood smears for estimating platelet count- A Quest for rapid screening method. CARE 2019
38 Dr Devi.S

Mr. Sabarinathan [AHS]

The effects of underfilled K2 EDTA vaccutainers in automated hematological blood cell indices CARE 2019
39 Dr.Arunadevi.D, MD (Pathology) student,

Prof. R.Vijayashree

Correlation Of Conventional Biomarkers With Hematological Parameters In Assessing The Disease Severity Of Psoriasis CARE 2017-2019
40 Dr.Chitra.K, MD (Pathology) student.

Dr. Sushma Nayar

Expression of PD L-1, Bcl-2, Ki-67 in breast cancer; with clinicopathological correlation NIL 2017-2019
41 Dr. Sowmya.D, MD (Pathology) student,

Prof. R.Vijayashree

Expression of Sox-2 in normal, intraepithelial and invasive cervical cancer and its correlation with clinico-pathological parameters NIL 2017-2019
42 Prof. Vijayashree

Ms. Divyashree

Correlation of complete haemogram, Iron profile & pH of cord blood of Newborn with APGAR score & gravid status of mother – A Prospective Observational study ICMR STS 2019
43 Prof. Rajesh Kanna

Ms. S Sindhuja

To determine the association of Helicobacter pylori infection with Neutrophil-Lymphocyte ratio, Mean Platelet Volume, Volume Conductance Scatter characteristics of LH 780 coulter hemoanalyser. ICMR STS 2019
44 Dr S Devi

Ms. Yogambal

Manual liquid-based cytology using needle rinse material – a cost and resource effective technique to enhance diagnostic accuracy of fine needle aspirates. ICMR STS 2019
45 Dr. Chidambharam

Ms.VennelaNelakuditi

Exploring the role of natural inks in surgical pathology: Analysis of leaching of colourwith natural inks and comparison of natural, acrylic inks with standard inks ICMR STS 2019
46 Dr. Femela. M,

Ms. Nandhini

Study of the effect of platelet transfusion on the platelet count CARE 2019
47 Dr. Rajeswari Thivya,

Ms. Salam Regina Chanu

Evaluation of hemoglobin concentration after packed cell transfusion CARE 2019
S.No Date Conference/workshop/CME Topics Speakers
1 17.11.2012 CME on Soft Tissue Tumours

Number of participants- 125

Number of posters displayed- 25

Cytodiagnosis of Soft tissue Merits and Demerits

Pattern approach, IHC and cytogenetic profile and reporting guidelines for soft tissue sarcomas

Soft tissue pseudosarcomas and recently categorized soft tissue tumours

Prof Karkuzhali (Director in charge, Institute of Pathology, MMC)

Prof Prathiba (Prof Department of Pathology, SRU)

Prof Geetha Prakash (HOD & Professor, Department of pathology, MAHER University)

2 Jan 2013 CME Approach to anemia Dr. Vijay
Asst prof,
CHRI
3 Aug 2014 CME Role of personalized medicine/molecular diagnostics in non-small cell carcinoma Dr. Chidambharam
4 3.4.2015 CME Immunohistochemistry in surgical pathology Dr. Rajesh Kanna Associate prof CHRI
5 19.11.2016 CME on Lymphoma Update 2016

Number of participants- 200

Number of posters displayed- 11

1. WHO Classification of Lymphoid Neoplasms -2016

2.Classification and Prognostication of Diffuse Large B-Cell Lymphoma

3. Slide Discussion
Extranodal Lymphoma – A Surgical Pathologist perspective
Lymphoma Mimics – A pattern Approach

Dr. S. Shirley, Professor & HOD, Dept of Pathology, Adyar Cancer Institute, Chennai

Dr. K R. Chatura, Professor, Dept of Pathology, JJM Medical College, Davengere

Dr. Debdatta Basu, Professor, Dept of Pathology JIPMER, Pondicherry

6 August 2016 CME BT and CT as presurgical evaluator tests Dr. Chidambharam
Asst Prof
CHRI
7 18.11.2017 City pathology meet Rare progression to malignancy from benign tumours: 2 case reports Dr. Chidambharam
Asst Prof
CHRI
8 27.01.2018 CME
Number of participants-28
1. Clinic-radiological features and differential diagnosis of Giant cell rich lesions of bone

2. Histopathological approach to Giant cell rich lesions of bone

Dr. Chennakeshava Rao
Professor & Head, Director of Department of Orthopaedics, KVG medical college, Karnataka

Dr. Anuradha Rao
Professor, Dept of Pathology, Yenepoya Medical College, Karnataka

9 31.08.2018 CME

Number of participants-66

Approach to soft tissue lesions Dr.Chandramouleeswari
Professor and Head, Department of Central Laboratory, TNGMSSH, Chennai
10 17.11.2018 CME

Number of participants- 66

Number of posters displayed- 08

Gastrointestinal pathology-an update Dr. G. Manoharan
Professor, Inst of Surgical GE & Liver Transplantation, Govt. Stanley Medical College

Dr. Sandhya Sundaram
Prof & HOD, SRMC

Dr. R. Padmavathy
Professor, Institute of Pathology, MMC.

Dr. S. Shirley
Prof & HOD, Adyar Cancer Institute

Dr. Mukul Vij
Senior Consultant, Histopath, Global hospitals

11 30.08.2019 Total: 20 Recent trends in paediatric CNS tumours Dr. K Rama, Prof of neuropathology, Institute on neurology, MMC,Chennai
12 27. 09.2019 Total: 40 Approach to hemoglobinopathies Dr. Mamta Soni
HOD, clinical lab Appolo hospitals, Chennai

Dr. Aruna Rajendran Paediatric hemato-oncologist, BMT physician, ICH Egmore

13 4&5. 02.2020 Workshop: 34

CME: 54

Workshop on molecular diagnostic techniques and CME on diagnostic molecular pathology Dr. S. Shirley
Prof & HOD, Adyar Cancer Institute

Dr. Shilpa Rao
Assistant Professor, NIMHANS, Bengaluru.

Dr. Biswajit Dubashi
Additional Professor & HOD, Dept. of Medical Oncology,
JIPMER, Puducherry.

Dr. Kumaresan Ganesan
Professor, Head & Chairperson, Dept. of Genetics, Unit of
Excellence in Cancer Genetics Centre for Excellence in
Genomic Sciences, School of Biological Sciences, Madurai
Kamaraj University, Madurai.

14 13.06.2020 Total: 64 Webinar
Practical approach to platelet refractoriness
Dr. Anisha Navkudkar, MD
Consultant Tata Mumbai Hospital, Mumbai
15 1&2.07.20 1.7.20 – 168

2.7.20 – 158

Webinar
Approach to hemoglobinopathies
Dr. Mamta Soni, MD
HOD, Haematology & Clinical Pathology, APOLLO HOSP, Chennai
16 15.07.2020 Total: 81 Webinar
Scientific publishing in medicine: facts, foes and future
Dr. Preithy Uthamalingam
MD, FRCP (UK)
17 20&21.7.20 20.7.20 – 138

21.7.20 – 129

Webinar
Approach to glomerular disease
Dr. Vikram Raj Gopinathan, MD
Assistant Professor, Christian Medical College, Vellore

ANGIOLEIOMYOMA

Fig.1: Fascicles of smooth muscle surrounding vessels Fig. 2: Diffuse Smooth muscle actin positivity in the tumor cells

Immunofluorescence & Silver Stain Kidney – Lupus Nephritis

 

PLEOMORPHIC HYALINIZING ANGIECTATIC TUMOR

Figure 1. A: Gross; B: Microscopic appearance of the tumor (H & E, 40X)

METASTATIC MENINGIOMA IN PLEURA

 

Figures 2a-2d: Microscopic picture of the metastatic meningioma (a: nests of tumor cells; b: tumor cells with clear cytoplasm; d: necrotic focus; e: EMA positivity; f: Vimentin positivity)

ANENCEPHAL

 

Figures 2a-2d: Microscopic picture of the metastatic meningioma (a: nests of tumor cells; b: tumor cells with clear cytoplasm; d: necrotic focus; e: EMA positivity; f: Vimentin positivity)


Department of Pathology

About the Department

The Department of Pathology was established in 2005. The Department strives to provide excellence in teaching, diagnostic services and research and is well recognized for its dedicated and innovative approach towards providing accurate and timely diagnostic services in all facets of surgical & anatomic pathology, haematology, coagulation,clinical pathology and cytology to patients from Chengalpattu district, Chennai and other cities of Tamil Nadu& neighboring states.

The Team

Department of Pathology is presently headed by Prof. Dr. R. Vijayashree,who has an experience of 20 years in both diagnostic and teaching services and about 30 publications to her credit. The young vibrant team of pathology consists of well qualified.(MD/DNB) and trained faculty (professors, associate professor & assistant professor & tutors) and has established its mark in all three aspects of Heath care, Patient Care, Teaching & Research.

Diagnostic Services

The hematology, clinical pathology, cytology & histopathology basic services are available round the clockand are complemented by specialized Rapid Diagnostic Frozen section, Immunohistochemistry & Immunofluorescence services in both adult & Paediatric pathology,all under one roof which is NABL accredited laboratory since 2009.

The laboratory is well equipped with state of art equipment including Fully Automated Haematology Analyzers, Automated Coagulation Analyzers, Automated ESR Analyzer, Automated Urine analyzer, and QBC for MP/MF. Apart from these, Rapid Tissue Processors, Automated Paraffin Embedding Stations, Automated Microtomes for tissue sectioning, Cryostats (Rapid Tissue sections) and Multi-headed (Decahead) microscopes. All laboratory test results are available through the hospital intranet, as part of the Laboratory Information System (LIS).We are committed to a rapid turn-around-time while providing the highest quality patient care.

3.1. Blood Bank (Diagnostic & Therapeutic services)

  • The Blood Bank works 24 x7 to cater to the blood component requirements of the hospital. We have an active component preparation section. Currently we are preparing components in more than 98% of collections.
  • The Serology section has an Automated System (Gel Technology) for reporting of blood groups and other immunohaematological tests. The Blood bank has facilities to investigate for a limited red cell antibody screening and identification.
  • The blood bank also has facilities for Plasma & single donor Platelet pheresis to cater to patients with GBS, Dengue fever, Thrombocytopenia. The blood bank provides exchange transfusion therapy for patients with Rat Killer poisoning. Blood Bank provides support to patients with Hemophilia and related Bleeding disorders and Thalassemia

Teaching

The Department of Pathology deals with teaching responsibilities as well. Department is involved in teaching Undergraduate (MBBS) and Postgraduate (MD Pathology) Medical students, Undergraduate and Postgraduate Allied Health Sciences Students, Undergraduate & postgraduate Physiotherapy, Pharmacy, Nursing and Dental Students.We have a large museum with a display of around 350 mounted specimens in all systems and 600 wet specimens for postgraduate learning.

Undergraduate training & learning is accomplished by means of Interactive lectures and small group discussions, Assignments, Seminar presentation, Case resolutions.Innovative Teaching Learning and Evaluation Methods for Undergraduates include the introduction of integrated OSPE stations for urine analysis & blood grouping, Project Exhibitions, Quiz/Debate, Problem Based Learning and Online Image Quiz

Training Programsfor Postgraduatesincludesslidediscussions, discussions on morbid anatomy,short topics, techniques, Journal club, student seminars, Autopsy Discussions, Periodical thesis reviews. Scheduled rotational postings in subspecialty departments are also organized. Interdepartmental meets conducted once in a month with the clinical departments. Faculty also participate and present cases in Clinicopathological meets. Innovative Teaching Learning Methods for Postgraduates include the introduction of integrated OSPE stations for histopathology techniques, E based learning of gross & histopathology case discussions, Skill Lab, Gross Photography and Mounting Specimens

Knowledge is imparted to the Allied Health Science students thorough theory classes, clinical case discussion, hands on training and they also have to submit a research project.

Faculty regularly update their knowledge by attending workshops and conferences and faculty development programs to hone their teaching skills.

Research

All faculty actively participate in research with many completed projects, ongoing projects and publications individually. Also, department is involved in many collaborative research projects from College of Allied Health Sciences including Molecular/Genomic/Nanotechnology areas.

Major thrust area for research include Molecular Biomarkers Study in Breast Cancer, Chronic diseases like Psoriasis, H.pylori induced Gastritis and Adenocarcinoma, Ovarian Malignancies, Cervical Neoplasia and Colorectal Carcinomas.

The Department actively organizes conferences and CMEs on updates in pathology inviting eminent pathologists and scientists for guest lectures. Faculty and PG/UG students’ active participation in Local, Regional, National & International conferences including giving Guest Lectures, Chairing scientific sessions and Oral paper/Poster presentations.

Completed & Ongoing Projects – 50 completed projects in last 10 years and 10 ongoing projects in the current year. Publications – 85 publications in last 10 years in Local, State, National & International level Journals with 50% in Scopus& WoS.

25 ICMR STS projects have been awarded in Pathology from 2008 till date, in addition to 25 CARE funded projects & 2 Care Seed projects

Hematology

  • Hematology & Immunohematology
    Complete Haemogram, QBC, Osmotic Fragility tests, HPLC in conjunction with Biochemistry, clinical workups for hemolytic & Nutritional Anemias, DCT & ICT
  • Coagulation profile studies including routine PT/APTT, mixing studies, Fibrinogen, D-Dimer and selective Factor assay, Work up of Bleeding and thrombotic disorders.

Clinical Pathology

Clinical Pathology services include Automated Urinanalysis, all Body fluid tests & Semen analysis.Clinical Pathologists perform quality assurance and supervision, provide interpretations of more complex results, and serve as consultants to clinicians to determine the appropriate testing for the diagnosis or the assessment of an individual patient’s condition.

Histopathology

  • Histopathology section including Synaptic Reporting of Breast, Colon, Stomach, Ovarian& Uterine Carcinomas–we as anatomic pathologists have been moving more and more toward the molecular level to gain additional clinical information on individual specimens. Surgical pathology is a large area of practice for anatomic pathologists, involving examination of surgical specimens and biopsies from patients.
  • Frozen Sections for rapid diagnosis including intra-operative consultations by the department of pathology
  • Transplant biopsies (Renal, &Liver) are reported periodically.
  • Autopsy pathology accounts for less than ten percent of the work of pathologists, it is the most commonly understood function of the pathologist. Clinical Fetal Autopsy services- Autopsies remain an important area of the modern practice of pathology and they are often equated in the popular imagination with it.

Cytopathology

Cytopathology service provides a full range of cytology services, including exfoliative cytology and the performance of fine needle aspiration under guidance or freehand.

Specialized Services

  • Immunofluorescence on renal and skin biopsies
  • Immunohistochemistry with a panel of about 40 antibodies in all Breast cancers, GIT cancers, Small blue round cell tumours, Soft tissue sarcomas, Lymphoproliferative disorders & Undifferentiated malignancies
  • Department of Pathology focuses on an integrative approach to the field, in which scientists and physicians strive to work in conjunction with each other to integrate the knowledge gained in research with the needs for patient care.
  • Apart from academic excellence, the Department aims to strengthen molecular pathology with our College of Allied Health Sciences Molecular Department to enhance the efficiency of subspecialty branches under Pathology and also strives towards becoming a collaborative high impact research facility.

Ongoing Projects
Completed projects

S.No Name of the Investigators Title Funding Agency(if any) Period
1 Dr. C. Chidambharam, Assistant Professor,

Mr. Anish Sunder Narayanan

Effect of adjusted and non-adjusted citrate concentrations on coagulation test results in patients with high haematocrit values – Breaking the unproven leap of faith ICMR STS 2011
2 Ms. S. Valli (MBBS student),

Dr. Rajesh Kanna, Assistant Professor

Relation between Diabetes mellitus type 2 and cognitive impairment, a predictor of Alzheimer’s disease ICMR STS 2011
3 Mr Treshul Kumar (MBBS student),

Prof Dr S Balamurugan

Automated Measurement of Immature Granulocytes : Performance Characteristics and Utility in Routine Clinical Practice ICMR STS 2011-12
4 Prof S. Balamurugan Reagent Strip Testing for Asymptomatic Bacteriuria in Pregnant Women : A Cost Effective Screening Tool in Under-sourced Settings CARE 2011-12
5 Dr R Vijayashree (Associate Professor)

MsTejasvee (MBBS student),

Relation between Lung function and RBC distribution width in a population based study ICMR STS 2012
6 Dr. Aruthra (MD student, Pathology) Molecular subtyping of Breast Carcinoma Using IHC and Clinico-pathological Correlation CARE 2012-14
7 Dr. M. Femela, Assistant Professor Evaluation of auto analyzer generated pseudobasophilia. CARE 2012-14
8 Ms. Bageerathi (MBBS student),

Dr. Sushma Nayar, Associate Prof

Risk Factors For Coronary Artery Disease in a Semi-urban Area of Tamil Nadu, Especially Pertaining to Tobacco Use ICMR STS 2013
9 Ms.Swathika(MBBS student),

Dr. Aarthi Kannan, Assistant Prof

Effects of Thyroid Dysfunction on Prothrombin Time and Activated Partial Thromboplastin Time ICMR STS 2013
10 Dr.R.Vijayashree, Associate Professor

V. R. Abhirami (MBBS student),

RDW as a Prognostic Marker in Patients with Stroke ICMR STS 2014
11 Ms. Preethi Ravi (MBBS student),

Dr. S. Devi

Predictive Value of Platelet Indices in the Spectrum of Ischaemic Heart Disease ICMR STS 2014
12 K. Hemanth Kumar (MBBS student),

Prof. Dr. S. Balamurugan

Self-directed Learning Among UG Medical Students ICMR STS 2014
13 Mr. Diwaker (BDS student)

Associate Prof Dr. N. R. Rajesh Kanna

MPV in Type II Diabetes Mellitus ICMR STS 2014
14 Dr P Aruthra (MD student, Pathology),

Dr R Vijayashree,

Dr Ramesh Rao

Automated Quantitation of Receptor status of breast carcinoma with Immunohistochemical reclassification CARE 2014-15
15 Dr R Vijayashree,

Dr K Ramesh Rao

Morphometric Assessment of Nuclei in Squamous cell carcinoma in comparison with Pseudoepitheliomatous hyperplasia and Verrucous carcinoma – An image J Based semi-Automated study CARE 2014-15
16 Dr R Vijayashree,

Dr K Ramesh Rao

Morphometric Assessment of Nuclei in Pap Smears with Reactive changes, ASCUS, LSIL & HSIL using ImageJ – Semi Automated analysis. CARE 2014-15
17 Dr. Siva Prashanth (MD student, Pathology),

Prof. k. Ramesh Rao

Relationship Between Red Cell Distribution Width And Other Haematological Parameters With HbA1C Values In Diabetic Patients CARE 2014-15
18 Dr K Sivaprashanth (MD student, Pathology),

Prof K Ramesh Rao

Platelet indices and other haematological parameters in Type II DM with complications CARE 2014-15
19 Dr. Teena Eugene (MD student, Pathology),

Prof. R. Vijayashree,

Dr. Rajesh Kanna (Associate Professor)

Rapid Intraoperative Diagnosis of CNS Tumors by Squash Cytology and its Correlation with Histopathology CARE 2014-16
20 Dr R Vijayashree, Professor

Ms Dhamini Gunasekaran (MBBS student)

Relevance of Haematologic Parameters in Obese Women with or without Metabolic Syndrome. ICMR STS 2015
21 Dr Teena Eugene,

Dr R Vijayashree,

Dr Rajesh Kanna

Rapid Intraoperative Diagnosis of CNS Tumors by Squash Cytology and its Correlation with Histopathology CARE 2015
22 Dr R Vijayashree

Ms Abhinaya Kuberan (MBBS student)

MPV and other haematological parameters in psoriatic patients. ICMR STS 2016
23 Dr Rajesh Kanna,

Ms Snigdha (MBBS student)

Estimation of platelets counts and other haematological parameters in pseudothrombocytopenia using alternate anticoagulant Magnesium sulphate ICMR STS 2016
24 Dr Aarthi K, Assistant Professor,

Ms Pavithra Selvam (MBBS student)

The potential of using VCS parameters of neutrophils as an early diagnostic tool in acute bacterial infections. ICMR STS 2016
25 Dr FemelaMuniraj, Associate Professor,

Ms. Saipriya Mohan (MBBS student)

Comparison of the traditional method of counting platelets in peripheral smear with the alternative methods in case of Erythropenia. CARE 2016-17
26 Dr. S. Devi

Ms. Ananthalakshmi (MBBS student)

The effects of sample transport by pneumatic tube system on routine hematology and coagulation systems ICMR STS 2017
27 Dr Rajesh Kanna, Professor,

Ms. AbishkaufJenishBeautlin, AHS student

Correlation between cytology and histopathology of salivary gland lesions CARE 2017
28 Dr. Femela Muniraj, Associate Professor,

Ms. Helen Monisha, AHS student

Comparison of Papanicolaou and Diff-Quik stains in differentiation of round cells in semen. CARE 2017
29 Dr. R Vijayashree, Professor,

Ms. Maivizhi, MBBS student

Mean Platelet Volume and Red cell Distribution width in clinical and subclinical Hypothyroidism CARE 2017
30 Dr. Sushma Nayar,

Ms. SriRanjani, MBBS student

Rebound eosinophilia as a marker of recovery in dengue cases CARE 2017
31 Dr.Chidambharam, Assistant Professor,

Balamurugan, AHS student

Prevalence of pre-analytical errors in haematology laboratory CARE 2017
32 Dr.Aarthi K, Associate Professor,

Yogesh, AHS student

Comparison of rapid and conventional Pap stain in gynaecology and non-gynaceology specimens CARE 2017
33 Dr. Femela Muniraj, Associate Professor,

Ms. T. Radhalakshmi, MBBS student

Evaluation of Leucocyte Esterase Test in analysis of body fluids other than blood & urine using reagent strips CARE 2017-2018
34 Dr R Vijayashree

MsSarmita Pal, II yr MBBS

Effect of GERD on Pulmonary Function Test and hematological parameters Case Control study ICMR STS 2018
35 Dr ChidambharamMs Shruti,

II yr MBBS

Demystifying the mysteries of Megaloblastic Anemia: Volume, Conductance, Scatter of hypersegmented neutrophils and elucidating the pathogenesis of in vitro hemolysis in megaloblastic anemia ICMR STS 2018
36 Dr T Bhuvaneeswari

Ms. Malini II yr MBBS

The usefulness of cell population data of leucocytes in accurately predicting the etiology of acute febrile illness. ICMR STS 2018
37 Dr. BhuvaneeswariThiyagarajan,

M.kavitha, AHS student

A comparative study on the usefulness of unstained and stained peripheral blood smears for estimating platelet count- A Quest for rapid screening method. CARE 2019
38 Dr Devi.S

Mr. Sabarinathan [AHS]

The effects of underfilled K2 EDTA vaccutainers in automated hematological blood cell indices CARE 2019
39 Dr.Arunadevi.D, MD (Pathology) student,

Prof. R.Vijayashree

Correlation Of Conventional Biomarkers With Hematological Parameters In Assessing The Disease Severity Of Psoriasis CARE 2017-2019
40 Dr.Chitra.K, MD (Pathology) student.

Dr. Sushma Nayar

Expression of PD L-1, Bcl-2, Ki-67 in breast cancer; with clinicopathological correlation NIL 2017-2019
41 Dr. Sowmya.D, MD (Pathology) student,

Prof. R.Vijayashree

Expression of Sox-2 in normal, intraepithelial and invasive cervical cancer and its correlation with clinico-pathological parameters NIL 2017-2019
42 Prof. Vijayashree

Ms. Divyashree

Correlation of complete haemogram, Iron profile & pH of cord blood of Newborn with APGAR score & gravid status of mother – A Prospective Observational study ICMR STS 2019
43 Prof. Rajesh Kanna

Ms. S Sindhuja

To determine the association of Helicobacter pylori infection with Neutrophil-Lymphocyte ratio, Mean Platelet Volume, Volume Conductance Scatter characteristics of LH 780 coulter hemoanalyser. ICMR STS 2019
44 Dr S Devi

Ms. Yogambal

Manual liquid-based cytology using needle rinse material – a cost and resource effective technique to enhance diagnostic accuracy of fine needle aspirates. ICMR STS 2019
45 Dr. Chidambharam

Ms.VennelaNelakuditi

Exploring the role of natural inks in surgical pathology: Analysis of leaching of colourwith natural inks and comparison of natural, acrylic inks with standard inks ICMR STS 2019
46 Dr. Femela. M,

Ms. Nandhini

Study of the effect of platelet transfusion on the platelet count CARE 2019
47 Dr. Rajeswari Thivya,

Ms. Salam Regina Chanu

Evaluation of hemoglobin concentration after packed cell transfusion CARE 2019

Conferences & CME organized

S.No Date Conference/workshop/CME Topics Speakers
1 17.11.2012 CME on Soft Tissue Tumours

Number of participants- 125

Number of posters displayed- 25

Cytodiagnosis of Soft tissue Merits and Demerits

Pattern approach, IHC and cytogenetic profile and reporting guidelines for soft tissue sarcomas

Soft tissue pseudosarcomas and recently categorized soft tissue tumours

Prof Karkuzhali (Director in charge, Institute of Pathology, MMC)

Prof Prathiba (Prof Department of Pathology, SRU)

Prof Geetha Prakash (HOD & Professor, Department of pathology, MAHER University)

2 Jan 2013 CME Approach to anemia Dr. Vijay
Asst prof,
CHRI
3 Aug 2014 CME Role of personalized medicine/molecular diagnostics in non-small cell carcinoma Dr. Chidambharam
4 3.4.2015 CME Immunohistochemistry in surgical pathology Dr. Rajesh Kanna Associate prof CHRI
5 19.11.2016 CME on Lymphoma Update 2016

Number of participants- 200

Number of posters displayed- 11

1. WHO Classification of Lymphoid Neoplasms -2016

2.Classification and Prognostication of Diffuse Large B-Cell Lymphoma

3. Slide Discussion
Extranodal Lymphoma – A Surgical Pathologist perspective
Lymphoma Mimics – A pattern Approach

Dr. S. Shirley, Professor & HOD, Dept of Pathology, Adyar Cancer Institute, Chennai

Dr. K R. Chatura, Professor, Dept of Pathology, JJM Medical College, Davengere

Dr. Debdatta Basu, Professor, Dept of Pathology JIPMER, Pondicherry

6 August 2016 CME BT and CT as presurgical evaluator tests Dr. Chidambharam
Asst Prof
CHRI
7 18.11.2017 City pathology meet Rare progression to malignancy from benign tumours: 2 case reports Dr. Chidambharam
Asst Prof
CHRI
8 27.01.2018 CME
Number of participants-28
1. Clinic-radiological features and differential diagnosis of Giant cell rich lesions of bone

2. Histopathological approach to Giant cell rich lesions of bone

Dr. Chennakeshava Rao
Professor & Head, Director of Department of Orthopaedics, KVG medical college, Karnataka

Dr. Anuradha Rao
Professor, Dept of Pathology, Yenepoya Medical College, Karnataka

9 31.08.2018 CME

Number of participants-66

Approach to soft tissue lesions Dr.Chandramouleeswari
Professor and Head, Department of Central Laboratory, TNGMSSH, Chennai
10 17.11.2018 CME

Number of participants- 66

Number of posters displayed- 08

Gastrointestinal pathology-an update Dr. G. Manoharan
Professor, Inst of Surgical GE & Liver Transplantation, Govt. Stanley Medical College

Dr. Sandhya Sundaram
Prof & HOD, SRMC

Dr. R. Padmavathy
Professor, Institute of Pathology, MMC.

Dr. S. Shirley
Prof & HOD, Adyar Cancer Institute

Dr. Mukul Vij
Senior Consultant, Histopath, Global hospitals

11 30.08.2019 Total: 20 Recent trends in paediatric CNS tumours Dr. K Rama, Prof of neuropathology, Institute on neurology, MMC,Chennai
12 27. 09.2019 Total: 40 Approach to hemoglobinopathies Dr. Mamta Soni
HOD, clinical lab Appolo hospitals, Chennai

Dr. Aruna Rajendran Paediatric hemato-oncologist, BMT physician, ICH Egmore

13 4&5. 02.2020 Workshop: 34

CME: 54

Workshop on molecular diagnostic techniques and CME on diagnostic molecular pathology Dr. S. Shirley
Prof & HOD, Adyar Cancer Institute

Dr. Shilpa Rao
Assistant Professor, NIMHANS, Bengaluru.

Dr. Biswajit Dubashi
Additional Professor & HOD, Dept. of Medical Oncology,
JIPMER, Puducherry.

Dr. Kumaresan Ganesan
Professor, Head & Chairperson, Dept. of Genetics, Unit of
Excellence in Cancer Genetics Centre for Excellence in
Genomic Sciences, School of Biological Sciences, Madurai
Kamaraj University, Madurai.

14 13.06.2020 Total: 64 Webinar
Practical approach to platelet refractoriness
Dr. Anisha Navkudkar, MD
Consultant Tata Mumbai Hospital, Mumbai
15 1&2.07.20 1.7.20 – 168

2.7.20 – 158

Webinar
Approach to hemoglobinopathies
Dr. Mamta Soni, MD
HOD, Haematology & Clinical Pathology, APOLLO HOSP, Chennai
16 15.07.2020 Total: 81 Webinar
Scientific publishing in medicine: facts, foes and future
Dr. Preithy Uthamalingam
MD, FRCP (UK)
17 20&21.7.20 20.7.20 – 138

21.7.20 – 129

Webinar
Approach to glomerular disease
Dr. Vikram Raj Gopinathan, MD
Assistant Professor, Christian Medical College, Vellore

Interesting Cases

ANGIOLEIOMYOMA

Fig.1: Fascicles of smooth muscle surrounding vessels Fig. 2: Diffuse Smooth muscle actin positivity in the tumor cells

Immunofluorescence & Silver Stain Kidney – Lupus Nephritis

 

PLEOMORPHIC HYALINIZING ANGIECTATIC TUMOR

Figure 1. A: Gross; B: Microscopic appearance of the tumor (H & E, 40X)

METASTATIC MENINGIOMA IN PLEURA

 

Figures 2a-2d: Microscopic picture of the metastatic meningioma (a: nests of tumor cells; b: tumor cells with clear cytoplasm; d: necrotic focus; e: EMA positivity; f: Vimentin positivity)

ANENCEPHAL

 

Figures 2a-2d: Microscopic picture of the metastatic meningioma (a: nests of tumor cells; b: tumor cells with clear cytoplasm; d: necrotic focus; e: EMA positivity; f: Vimentin positivity)

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